The IAPP antibody - Human IAPP (amylin) 1-37, specific for the native hormone having a disulphide-bridge between Cys2-Cys7 from Agrisera is a Chicken/Bird Polyclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The IAPP antibody - Human IAPP (amylin) 1-37, specific for the native hormone having a disulphide-bridge between Cys2-Cys7 has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzherimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the deleopment of type 2 diabetes